Npgrj_nn_2057 334..343
نویسندگان
چکیده
Estrogens have long been implicated in influencing cognitive processes, yet the molecular mechanisms underlying these effects and the roles of the estrogen receptors alpha (ERa) and beta (ERb) remain unclear. Using pharmacological, biochemical and behavioral techniques, we demonstrate that the effects of estrogen on hippocampal synaptic plasticity and memory are mediated through ERb. Selective ERb agonists increased key synaptic proteins in vivo, including PSD-95, synaptophysin and the AMPAreceptor subunit GluR1. These effects were absent in ERb knockout mice. In hippocampal slices, ERb activation enhanced longterm potentiation, an effect that was absent in slices from ERb knockout mice. ERb activation induced morphological changes in hippocampal neurons in vivo, including increased dendritic branching and increased density of mushroom-type spines. An ERb agonist, but not an ERa agonist, also improved performance in hippocampus-dependent memory tasks. Our data suggest that activation of ERb can regulate hippocampal synaptic plasticity and improve hippocampus-dependent cognition.
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